Dr Martina Paglia talks about Depression. Everyone feels sad at times, but the sadness usually goes away. However for some people, these sad feelings remain for a long time. A person who feels bad about themselves for a long time might have depression. Depression is a mental health issue that affects an individual's moods. Moods are the way we feel and how we express those feelings. Someone who suffers from depression may feel angry, irritable, sad, tired, confused, guilty or worthless. A person who is depressed may lose interest in almost everything they used to enjoy. Depression can also cause physical changes in the body. Someone with depression may also have aches and pain or other health conditions. Depression can also change the way an individual behave. Somebody with depression may yell and throw things, eat too little or too much, have trouble sleeping or feel tired most of the time. Feeling low is a normal emotion to experience some times and determining when to seek treatment for low mood and depression can be difficult. Typically, when your low mood is preventing you from fulfilling your activities of daily living at work, school, or home, it is time to seek some help.